WebImmunohistochemistry revealed intense positive markers: NSE, chromogranin, synaptophysin CD56 and ki67=3%. The subsequent evaluations showed normal biological (CgA, serotonin, 5HIAA) and morphological (thoraco-abdominal CT) parameters until 2016, when CgA level was 7-fold higher that the upper normal value (545 ng/ml vs 76 ng/ml) … WebDec 20, 2024 · Numerous immunoassays have been developed to measure the levels of chromogranin A (CgA), a useful biomarker for diagnosing and monitoring generally heterogeneous neuroendocrine tumors (NETs). Here, we evaluated the imprecision and linearity of three such assays: KRYPTOR (ThermoFisher Scientific), NEOLISA …
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WebTypically, chromogranin A levels are around 2.5 times higher with the LC/MS/MS assay—this relationship is captured by the following equation: ELISA result = 13.6 + 0.36 … WebSep 21, 2016 · Chromogranin A (CgA) is an acidic glycoprotein with a molecular mass of 49 kd that is widely expressed by neuroendocrine cells and constitutes one of the most abundant components of secretory granules. 1 CgA is physiologically released by exocytosis and may be detected in the blood. In particular, when a tumor develops in an endocrine … bob\\u0027s stores locations in connecticut
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WebAn adjunct in the diagnosis of other neuroendocrine tumors, including pheochromocytomas, medullary thyroid carcinomas, functioning and nonfunctioning islet cell and gastrointestinal amine precursor uptake and decarboxylation tumors, … Web: mayocliniclabs.com: Email: [email protected]: Telephone: 800-533 … WebNormal range: < 2.5 ng/ml. Normal range may vary somewhat depending on the brand of assay used. Levels > 10 ng/ml suggest extensive disease and levels > 20 ng/ml suggest metastatic disease. C-erb B-2 (also called HER-2 or neu oncoprotein) Associated with larger sized tumors, shorter relapse time and lower survival rate. Chromogranin-A WebThe sensitivity and specificity of elevated CgA for the diagnosis of GEP-NEN range from 60% to 100%. 5–8 It has also been suggested that CgA may be a precious tool for predicting ... et al. Plasma chromogranin A response to octreotide test: prognostic value for clinical outcome in endocrine digestive tumors. Am J Gastroenterol 2010; 105:2072 ... cll chylothorax