Web1 okt. 2009 · It is shown that mice that carry a BAC transgene where single-amino-acid substitutions have been made in the Mitf gene rescue the phenotype of the loss-of … Web1 aug. 2015 · Thus, the activity of Mitf as a transcription factor appeared to promote its own cytoplasmic sequestration, a phenomenon consistent with increased TORC1 activity in …
Emerging roles and regulation of MiT/TFE transcriptional factors
Web7 apr. 2024 · On the while, MITF alone is not capable of transactivation of TRP2 (Potterf et al. 2001), and the association of MITF with other transcription factors plays a vital role to activate theTRP2 promoter (Ludwig et al. 2004; Vachtenheim and Borovansky 2010). cAMP plays a key role in MITF expression via phosphorylation of CREB (Roh et al. 2013). Web21 mrt. 2024 · MITF (Melanocyte Inducing Transcription Factor) is a Protein Coding gene. Diseases associated with MITF include Tietz Albinism-Deafness Syndrome and Melanoma, Cutaneous Malignant 8 . Among its … the weekend músicas
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Weband BRAF/MAPK signaling converges to control MITF nuclear export. Phosphorylation of the melanocyt e MITF-M isoform in response to BRAF/MAPK signaling primes for … Web26 dec. 2024 · Previous studies showed that the phosphorylation of ERKs, JNKs, p38, Akt, and S6K upregulated MITF translocation and tyrosinase expression in α-MSH-stimulated B16F10 cells. Therefore, we assume that phosphorylation levels of ERKs, JNKs, p38, Akt, and S6K may be more important for α-MSH-induced melanogenesis. Web23 jan. 2024 · MITF phosphorylation is short term and happens immediately after allergic trigger, since longer exposure time may lead to ubiquitin-mediated degradation, as was … the weekend music group