Nicotinic acetylcholine receptors, or nAChRs, are receptor polypeptides that respond to the neurotransmitter acetylcholine. Nicotinic receptors also respond to drugs such as the agonist nicotine. They are found in the central and peripheral nervous system, muscle, and many other tissues of many … Zobacz więcej Nicotinic receptors, with a molecular mass of 290 kDa, are made up of five subunits, arranged symmetrically around a central pore. Each subunit comprises four transmembrane domains with both the N- and C … Zobacz więcej As with all ligand-gated ion channels, opening of the nAChR channel pore requires the binding of a chemical messenger. … Zobacz więcej The activation of receptors by nicotine modifies the state of neurons through two main mechanisms. On one hand, the movement of Zobacz więcej The subunits of the nicotinic receptors belong to a multigene family (16 members in humans) and the assembly of combinations of subunits results in a large number of … Zobacz więcej Nicotinic AChRs may exist in different interconvertible conformational states. Binding of an agonist stabilizes the open and Zobacz więcej Desensitization Ligand-bound desensitization of receptors was first characterized by Katz and Thesleff in the … Zobacz więcej 17 vertebrate nAChR subunits have been identified, which are divided into muscle-type and neuronal-type subunits. Although an α8 subunit/gene is present in avian species such as the chicken, it is not present in human or mammalian species. The nAChR … Zobacz więcej

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Who let the spikes out? Nature Neuroscience

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